THORNE – Methyl-Guard Plus – Active Folate (5-MTHF) with Vitamins B2, B6 & B12 – Supports Methylation & Healthy Level of Homocysteine* – Gluten, Dairy & Soy-Free – 30 Servings

Price: $62.00
(as of Jul 14, 2026 12:24:21 UTC – Details)
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Product description

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Customer Reviews

4.7 out of 5 stars 1,772

4.3 out of 5 stars 7,443

4.7 out of 5 stars 16,960

4.7 out of 5 stars 2,608

4.6 out of 5 stars 3,151

4.4 out of 5 stars 6,426

4.4 out of 5 stars 2,533

Price

$62.00$62.00

$36.00$36.00

$44.00$44.00

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$41.00$41.00

$44.00$44.00

$52.00$52.00

Servings

30

30

90

90

90

30

60

Primary Benefits

Methylation

Foundational Support

Sports Performance

Muscle & Sleep Support

Heart & Brain Health

Heart & Gut Health

Muscle & Sleep Support

Key Ingredients

Riboflavin

Vitamin B, Magnesium

Creatine Monohydrate

Magnesium Glycinate

Omega-3 Fatty Acids

Berberine Phytosome

Magnesium

Gluten & Dairy Free

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Trusted by 45K+ Health Pros

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3rd Party Certified

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What makes Thorne supplements high quality?

Thorne produces high-quality supplements through rigorous testing, well-researched ingredient sourcing, and strict manufacturing standards. We avoid unnecessary additives, binders, and fillers that may interfere with nutrient absorption.

How does Thorne test its supplements for quality?

To confirm the purity of our ingredients, the potency of our formulas, and the absence of all contaminants, we carry out a minimum of four rounds of testing on every product we manufacture. 100+ Thorne employees are dedicated to ensuring quality.

Are Thorne supplements clinically tested and safe?

Thorne partners with researchers and conducts clinical trials to support the efficacy of our products. Our team of doctors and medical experts substantiate each ingredient in every formula based on extensive clinical research and medical literature.

Why are Thorne products more expensive than other supplements?

When it comes to the health of our customers, we never settle. Thorne products may be priced higher than some others because of our commitment to quality at every step. We don’t simply meet the standard in dietary supplements — we set the standard.

Where are Thorne supplements made and where are the ingredients sourced from?

Located in South Carolina, Thorne manufactures supplements in the USA using globally sourced ingredients. When it comes to ingredient sourcing, we seek out only the highest-quality ingredients, selecting each one for its purity and effectiveness.

Is Discontinued By Manufacturer ‏ : ‎ No
Product Dimensions ‏ : ‎ 2.38 x 2.38 x 4.23 inches; 3.84 ounces
Item model number ‏ : ‎ No Model
Department ‏ : ‎ All Ages
Date First Available ‏ : ‎ March 8, 2011
Manufacturer ‏ : ‎ Thorne Research
ASIN ‏ : ‎ B00O5AHC4S
Best Sellers Rank: #5,724 in Health & Household (See Top 100 in Health & Household) #104 in Blended Vitamin & Mineral Supplements #578 in Diet & Sports Nutrition
Customer Reviews: 4.7 4.7 out of 5 stars (1,772) var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
Healthy Methylation: Provides B vitamins and other nutrients that optimize methylation and promote a healthy level of homocysteine in the bloodsteam*
Active Forms: Formulated with superior methyl donors, including betaine and active folate (5-MTHF) and B12 (as methylcobalamin), to optimize utilization in the body
Heart and Brain Benefits: Sustains cardiovascular health and promotes healthy brain function by supporting neurotransmitter production and enhancing cellular energy levels*
4 Rounds of Testing: Our state-of-the-art laboratories enable us to conduct 4 rounds of testing on every product, from analyzing the purity of raw materials to confirming the shelf life of finished formulas
Trusted: Thorne is trusted by 100+ professional sports teams and the #1 most recommended clinical brand by consumers and health-care practitioners (Based on a 2026 independent survey of US supplement consumers and health-care practitioners)